Freshman, Ace Baldwin Jr., hit two free throws with 4.5 seconds on the clock to push the Rams to victory against the Billikens, 67-65.
Saint Louis was able to get a final shot off, but it would rim out as the clock expired.
VCU (17-5, 10-3 A10) was without the service of leading-scorer Bones Hyland who was resting his foot after a near-injury in the previous games loss to GMU.
The largest lead of the night was 8 points after the Rams got a three pointer from Vince Williams at the 18:05 mark of the second half.
Williams ended the night leading the Rams with both his 16 points and his 9 rebounds.
But the Billikens fought back and turned a 13-0 run into a 5 point lead with 14:37 to play.
In all, the game saw 18 lead changes and 14 ties.
The Rams only turned the ball over 7 times on the night, while forcing the Billikens into 15 total turnovers. Those 15 turnovers results in 13 points for the Rams.
VCU also racked up 6 steals on the evening and 7 blocks.
Baldwin secured three of those steals to go with his 15 points and his game-high 7 assists.
Levi Stockard and Jamir Watkins both finished the night with 9 points each for the Rams.
The Rams return to action on Saturday, February 27th, as they travel to North Carolina to take on Davidson. That game is set to tip at 2pm EST and will be broadcast on ESPN.