With the game clock about the expire, Luka Brajkovic spotted up for what looked like a clean look at the go-ahead shot.
But, Mikeal Brown-Jones covered the distance and stretched out to come up with the pivotal play of the game as he blocked the shot.
The loose ball then forced Davidson to foul VCU and send Brown-Jones to the FT line at the other end of the court.
Davidson was able to get a shot at the buzzer, but the attempt feel well short as the buzzer sounded and secured the Top-25 win for the Rams, 70-68
The loss ended a 15-game win streak for the Wildcats, a record that was tied for best in the country before tonight..
VCU (12-6; 5-2 A10) was looking to shake off a loss to the same Wildcats from just 8-days earlier.
The Rams shot an impressive 51% on the road, including 7-14 from range.
Vince Williams led the charge for the Rams with both 16 points and 6 rebounds. Williams was also 2-3 from deep.
Both Williams and Ace Baldwin connected on 6-9 of the shots from the floor.
Baldwin ended the night with 15 points, including 2-2 from range, and a game-high 5 steals.
Levi Stockard was the only other Ram in double-digit scoring with 12 points on 4-6 shooting from the floor, and a respectable 4-5 from the free throw line.
Brown-Jones ended the night with 2 points, 4 rebounds, and 1 potentially game-saving block.
The Rams had one of their best games of the year in terms of protecting the ball with only 7 turnovers for the entire 40 minutes.
The Wildcats committed 15 turnovers that led to 16 points for VCU.
The defense for the Rams continued to be the star as VCU held the Wildcats to just 3-14 shooting from distance for the game.
The Rams return to action on Saturday, January 29th, as they head just across the city lines to take on the University of Richmond Spiders.
That game is set to tip at 4pm EST and will be broadcast on CBS Sports Network.